解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Cancer-associated systemic inflammation is strongly linked to poor disease outcome in patients with cancer1,2. For most human epithelial tumour types, high systemic neutrophil-to-lymphocyte ratios are associated with poor overall survival3, and experimental studies have demonstrated a causal relationship between neutr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1450-6
更新日期:2019-08-01 00:00:00
abstract::De novo-designed proteins1-3 hold great promise as building blocks for synthetic circuits, and can complement the use of engineered variants of natural proteins4-7. One such designer protein-degronLOCKR, which is based on 'latching orthogonal cage-key proteins' (LOCKR) technology8-is a switch that degrades a protein o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1425-7
更新日期:2019-08-01 00:00:00
abstract::The global mid-ocean ridge system is the most extensive magmatic system on our planet and is the site of 75 per cent of Earth's volcanism1. The vertical extent of mid-ocean-ridge magmatic systems has been considered to be restricted: even at the ultraslow-spreading Gakkel mid-ocean ridge under the Arctic Ocean, where ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1448-0
更新日期:2019-08-01 00:00:00
abstract::Macrophages are considered to contribute to chronic inflammatory diseases such as rheumatoid arthritis1. However, both the exact origin and the role of macrophages in inflammatory joint disease remain unclear. Here we use fate-mapping approaches in conjunction with three-dimensional light-sheet fluorescence microscopy...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1471-1
更新日期:2019-08-01 00:00:00
abstract::An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1455-1
更新日期:2019-08-01 00:00:00
abstract::Change history: In this Letter, the bottom blot in Fig. 2g (for 'IB: Myc') was missing. This has been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1360-7
更新日期:2019-07-01 00:00:00
abstract::In this Article, in Fig. 1a, the 5' and 3' labels were reversed in the DNA sequence, and Fig. 4 was missing panel labels a-e. These errors have been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1343-8
更新日期:2019-07-01 00:00:00
abstract::Earth's climate history is often understood by breaking it down into constituent climatic epochs1. Over the Common Era (the past 2,000 years) these epochs, such as the Little Ice Age2-4, have been characterized as having occurred at the same time across extensive spatial scales5. Although the rapid global warming seen...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/s41586-019-1401-2
更新日期:2019-07-01 00:00:00
abstract::Ordinarily, photons do not interact with one another. However, atoms can be used to mediate photonic interactions1,2, raising the prospect of forming synthetic materials3 and quantum information systems4-7 from photons. One promising approach combines highly excited Rydberg atoms8-12 with the enhanced light-matter cou...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1354-5
更新日期:2019-07-01 00:00:00
abstract::Silicon dominates contemporary solar cell technologies1. But when absorbing photons, silicon (like other semiconductors) wastes energy in excess of its bandgap2. Reducing these thermalization losses and enabling better sensitivity to light is possible by sensitizing the silicon solar cell using singlet exciton fission...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1339-4
更新日期:2019-07-01 00:00:00
abstract::Change history: In this Letter, the final two pages of the Supplementary Information, which included two tables listing primer and antibodies, respectively, were missing; see accompanying Amendment for the missing Supplementary Tables. This Letter has not been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1328-7
更新日期:2019-07-01 00:00:00
abstract::Change history: In Fig. 1b and c of this Letter, the inset times in the DIC and GFP microscopy images should be in minutes ('min') instead of seconds ('s'). This has not been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1327-8
更新日期:2019-07-01 00:00:00
abstract::Mutations in the transcription factor FOXA1 define a unique subset of prostate cancers but the functional consequences of these mutations and whether they confer gain or loss of function is unknown1-9. Here, by annotating the landscape of FOXA1 mutations from 3,086 human prostate cancers, we define two hotspots in the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1318-9
更新日期:2019-07-01 00:00:00
abstract::Cryo-electron microscopy (cryo-EM) has the capacity to capture molecular machines in action1-3. ATP-binding cassette (ABC) exporters are highly dynamic membrane proteins that extrude a wide range of substances from the cytosol4-6 and thereby contribute to essential cellular processes, adaptive immunity and multidrug r...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1391-0
更新日期:2019-07-01 00:00:00
abstract::Human-mediated translocation of species to areas beyond their natural distribution (which results in 'alien' populations1) is a key signature of the Anthropocene2, and is a primary global driver of biodiversity loss and environmental change3. Stemming the tide of invasions requires understanding why some species fail ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1292-2
更新日期:2019-07-01 00:00:00
abstract::Mutations in BRCA1 and BRCA2 predispose individuals to certain cancers1-3, and disease-specific screening and preventative strategies have reduced cancer mortality in affected patients4,5. These classical tumour-suppressor genes have tumorigenic effects associated with somatic biallelic inactivation, although haploins...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1382-1
更新日期:2019-07-01 00:00:00
abstract::Cell-free DNA in the blood provides a non-invasive diagnostic avenue for patients with cancer1. However, characteristics of the origins and molecular features of cell-free DNA are poorly understood. Here we developed an approach to evaluate fragmentation patterns of cell-free DNA across the genome, and found that prof...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1272-6
更新日期:2019-06-01 00:00:00
abstract::The nucleus of mammalian cells displays a distinct spatial segregation of active euchromatic and inactive heterochromatic regions of the genome1,2. In conventional nuclei, microscopy shows that euchromatin is localized in the nuclear interior and heterochromatin at the nuclear periphery1,2. Genome-wide chromosome conf...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1275-3
更新日期:2019-06-01 00:00:00
abstract::Convection is a fundamental physical process in the fluid cores of planets. It is the primary transport mechanism for heat and chemical species and the primary energy source for planetary magnetic fields. Key properties of convection-such as the characteristic flow velocity and length scale-are poorly quantified in pl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1301-5
更新日期:2019-06-01 00:00:00
abstract::In Fig. 6a of this Article, the two dots corresponding to Cidea and S100b were erroneously moved to the top left of the volcano plot; this figure has been corrected online.An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1267-3
更新日期:2019-06-01 00:00:00
abstract::In mammals, the emergence of totipotency after fertilization involves extensive rearrangements of the spatial positioning of the genome1,2. However, the contribution of spatial genome organization to the regulation of developmental programs is unclear3. Here we generate high-resolution maps of genomic interactions wit...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1233-0
更新日期:2019-05-01 00:00:00
abstract::With the discovery1 of superconductivity at 203 kelvin in H3S, attention returned to conventional superconductors with properties that can be described by the Bardeen-Cooper-Schrieffer and the Migdal-Eliashberg theories. Although these theories predict the possibility of room-temperature superconductivity in metals th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1201-8
更新日期:2019-05-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequent development of dense stroma are prominent features accounting for this aggressive biology1,2. The reciprocal interplay betwe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1130-6
更新日期:2019-05-01 00:00:00
abstract::Nuclear magic numbers correspond to fully occupied energy shells of protons or neutrons inside atomic nuclei. Doubly magic nuclei, with magic numbers for both protons and neutrons, are spherical and extremely rare across the nuclear landscape. Although the sequence of magic numbers is well established for stable nucle...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1155-x
更新日期:2019-05-01 00:00:00
abstract::Combined PD-1 and CTLA-4-targeted immunotherapy with nivolumab and ipilimumab is effective against melanoma, renal cell carcinoma and non-small-cell lung cancer1-3. However, this comes at the cost of frequent, serious immune-related adverse events, necessitating a reduction in the recommended dose of ipilimumab that i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1162-y
更新日期:2019-05-01 00:00:00
abstract::In this Letter, the statement 'I.I. and A.B. performed computations at the NCI Australia' was missing from the Acknowledgements section. This has been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1123-5
更新日期:2019-05-01 00:00:00
abstract::Cell competition-the sensing and elimination of less fit 'loser' cells by neighbouring 'winner' cells-was first described in Drosophila. Although cell competition has been proposed as a selection mechanism to optimize tissue and organ development, its evolutionary generality remains unclear. Here, by using live imagin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1199-y
更新日期:2019-05-01 00:00:00
abstract::Intraplate magmatic provinces found away from plate boundaries provide direct sampling of the composition and heterogeneity of the Earth's mantle. The chemical heterogeneities that have been observed in the mantle are usually attributed to recycling during subduction1-3, which allows for the addition of volatiles and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1183-6
更新日期:2019-05-01 00:00:00
abstract::In this Letter, Supplementary Fig. 1 was missing. This error has been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1207-2
更新日期:2019-05-01 00:00:00
abstract::The study of language origin and divergence is important for understanding the history of human populations and their cultures. The Sino-Tibetan language family is the second largest in the world after Indo-European, and there is a long-running debate about its phylogeny and the time depth of its original divergence1....
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/s41586-019-1153-z
更新日期:2019-05-01 00:00:00
abstract::Large panels of comprehensively characterized human cancer models, including the Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study genetic variants, candidate targets, and small-molecule and biological therapeutics and to identify new marker-driven cancer dependencies. To imp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1186-3
更新日期:2019-05-01 00:00:00
abstract::Since Bridgman's discovery of five solid water (H2O) ice phases1 in 1912, studies on the extraordinary polymorphism of H2O have documented more than seventeen crystalline and several amorphous ice structures2,3, as well as rich metastability and kinetic effects4,5. This unique behaviour is due in part to the geometric...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1114-6
更新日期:2019-05-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) remains recalcitrant to all forms of cancer treatment and carries a five-year survival rate of only 8%1. Inhibition of oncogenic KRAS (hereafter KRAS*), the earliest lesion in disease development that is present in more than 90% of PDACs, and its signalling surrogates has yielde...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1062-1
更新日期:2019-04-01 00:00:00
abstract::In this Letter, in Fig. 3c and f the Saccharomyces cerevisiae and Escherichia coli networks were subject to both weight loss and node deletion, a combination of two types of perturbation, as opposed to weight loss only (as the labelling incorrectly indicated). The collapse in Fig. 3h was also obtained from this combin...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1091-9
更新日期:2019-04-01 00:00:00
abstract::Complex topological configurations are fertile ground for exploring emergent phenomena and exotic phases in condensed-matter physics. For example, the recent discovery of polarization vortices and their associated complex-phase coexistence and response under applied electric fields in superlattices of (PbTiO3)n/(SrTiO...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1092-8
更新日期:2019-04-01 00:00:00
abstract::The origins of religion and of complex societies represent evolutionary puzzles1-8. The 'moralizing gods' hypothesis offers a solution to both puzzles by proposing that belief in morally concerned supernatural agents culturally evolved to facilitate cooperation among strangers in large-scale societies9-13. Although pr...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/s41586-019-1043-4
更新日期:2019-04-01 00:00:00
abstract::Osteoclasts are multinucleated giant cells that resorb bone, ensuring development and continuous remodelling of the skeleton and the bone marrow haematopoietic niche. Defective osteoclast activity leads to osteopetrosis and bone marrow failure1-9, whereas excess activity can contribute to bone loss and osteoporosis10....
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1105-7
更新日期:2019-04-01 00:00:00
abstract::Global dust storms on Mars are rare1,2 but can affect the Martian atmosphere for several months. They can cause changes in atmospheric dynamics and inflation of the atmosphere3, primarily owing to solar heating of the dust3. In turn, changes in atmospheric dynamics can affect the distribution of atmospheric water vapo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1097-3
更新日期:2019-04-01 00:00:00
abstract::In this Letter, a citation to 'Fig. 1e' has been corrected to 'Fig. 1d' in the sentence starting "By contrast, the anti-tumour response…". This has been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1046-1
更新日期:2019-04-01 00:00:00
abstract::Interleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chronic inflammation in the gastrointestinal tract1-4. The protective effects of IL-2 involve the generation, maintenance and function of regulatory T (Treg) cells4-8, and the use of low doses of IL-2 has emerged as a potential therapeutic strat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1082-x
更新日期:2019-04-01 00:00:00